Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance
- Author(s)
- Kallies, A; Hawkins, ED; Belz, GT; Metcalf, D; Hommel, M; Corcoran, LM; Hodgkin, PD; Nutt, SL;
- Details
- Publication Year 2006-05,Volume 7,Issue #5,Page 466-474
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of terminal B cell differentiation, was expressed in a subset of antigen-experienced CD4(+) and CD8(+) T cells. Mice reconstituted with fetal liver stem cells expressing a mutant Blimp-1 lacking the DNA-binding domain developed a lethal multiorgan inflammatory disease caused by an accumulation of effector and memory T cells. These data identify Blimp-1 as an essential regulator of T cell homeostasis and suggest that Blimp-1 regulates both B cell and T cell differentiation.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- FACTOR FOXP3; CUTTING EDGE; MICE; AUTOIMMUNITY; EXPRESSION; LINEAGE; DIFFERENTIATION; EXPANSION; IL-21; INTERLEUKIN-2
- Publisher's Version
- https://doi.org/10.1038/ni1321
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-05-01 12:00:00