How robust is the evidence for viruses in the induction of type 1 diabetes?

Author(s): Honeyman, M;
Details: Publication Year 2005-12,Volume 17,Issue #6,Page 616-623
Journal Title: CURRENT OPINION IN IMMUNOLOGY
Publication Type: Journal Article
Abstract: Viruses associated with type 1 diabetes have eluded definition as causal, with the exception of rubella virus. False-negative results may have occurred due to the focus on subjects at symptomatic onset, who may be heterogeneous and differently affected by viruses. In addition, assays have not always been sufficiently sensitive to deal with transient infections, and pancreatic tissue is scarce. Longitudinal studies of at-risk subjects and more sensitive DNA techniques now reveal that at initiation of islet autoimmunity, enteroviruses have only a small role, but are more likely to be important at symptomatic onset. Rotavinuses remain associated with initiation of islet autoirnmunity, and generate strong T cell responses in the young.
Publisher: CURRENT BIOLOGY LTD
Keywords: BETA-CELL AUTOIMMUNITY; ISLET AUTOIMMUNITY; T-CELLS; CONGENITAL-RUBELLA; RISING INCIDENCE; COXSACKIE-VIRUS; MELLITUS; INFECTION; CHILDREN; INSULIN
Publisher's Version: https://doi.org/10.1016/j.coi.2005.09.007
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2005-12-01 12:00:00