The mitochondrial death squad: hardened killers or innocent bystanders?

Author(s): Ekert, PG; Vaux, DL;
Details: Publication Year 2005-12,Volume 17,Issue #6,Page 626-630
Journal Title: CURRENT OPINION IN CELL BIOLOGY
Publication Type: Journal Article
Abstract: Since the discovery that formation of the apoptosome in mammalian cells is triggered by cytochrome c released from the mitochondria, many other mitochondrial proteins have been suspected to be part of a conspiracy to cause cell death. AIF, EndoG, ANT, cyclophilin D, Bit1, p53AIP, GRIM-19, DAP3, Nur77/TR3/NGFB-1, HtrA2/Omi and Smac/Diablo have all been convicted as killers, but new genetic technology is raising questions about their guilt. Gene knockout experiments suggest that many were wrongly convicted on circumstantial evidence, and just happened to be in the wrong place at the wrong time.
Publisher: CURRENT BIOLOGY LTD
Keywords: PROGRAMMED CELL-DEATH; PERMEABILITY TRANSITION PORE; APOPTOSIS-INDUCING FACTOR; CYTOCHROME-C; ENDONUCLEASE-G; CYCLOPHILIN-D; CASPASE ACTIVATION; STRUCTURAL BASIS; IN-VIVO; PROTEIN
Publisher's Version: https://doi.org/10.1016/j.ceb.2005.09.001
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2005-12-01 12:00:00