The murine stanniocalcin 1 gene is not essential for growth and development

Author(s): Chang, ACM; Cha, J; Koentgen, F; Reddel, RR;
Details: Publication Year 2005-12,Volume 25,Issue #23,Page 10604-10610
Journal Title: MOLECULAR AND CELLULAR BIOLOGY
Publication Type: Journal Article
Abstract: The stanniocalcin 1 (STC1) gene is expressed in a wide variety of tissues, including the kidney, prostate, thyroid, bone, and ovary. STC1 protein is considered to have roles in many physiological processes, including bone development, reproduction, wound healing, angiogenesis, and modulation of inflammatory response. In fish, STC1 is a hormone that is secreted by the corpuscles of Stannius and is involved in calcium and phosphate homeostasis. To determine the role of STC1 in mammals, we generated Stc1-null mice by gene targeting. The number of Stc1(-/-) mice obtained was in accordance with Mendelian ratios, and both males and females produced offspring normally. No anatomical or histological abnormalities were detected in any tissues. Our results demonstrated that Stc1 function is not essential for growth or reproduction in the mouse.
Publisher: AMER SOC MICROBIOLOGY
Keywords: MOLECULAR-CLONING; TRANSGENIC MICE; EXPRESSION; MOUSE; PROTEIN; BONE; MUSCLE; CELLS; CDNA; STANNIUS
Publisher's Version: https://doi.org/10.1128/MCB.25.23.10604-10610.2005
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2005-12-01 12:00:00