The murine stanniocalcin 1 gene is not essential for growth and development
Details
Publication Year 2005-12,Volume 25,Issue #23,Page 10604-10610
Journal Title
MOLECULAR AND CELLULAR BIOLOGY
Publication Type
Journal Article
Abstract
The stanniocalcin 1 (STC1) gene is expressed in a wide variety of tissues, including the kidney, prostate, thyroid, bone, and ovary. STC1 protein is considered to have roles in many physiological processes, including bone development, reproduction, wound healing, angiogenesis, and modulation of inflammatory response. In fish, STC1 is a hormone that is secreted by the corpuscles of Stannius and is involved in calcium and phosphate homeostasis. To determine the role of STC1 in mammals, we generated Stc1-null mice by gene targeting. The number of Stc1(-/-) mice obtained was in accordance with Mendelian ratios, and both males and females produced offspring normally. No anatomical or histological abnormalities were detected in any tissues. Our results demonstrated that Stc1 function is not essential for growth or reproduction in the mouse.
Publisher
AMER SOC MICROBIOLOGY
Keywords
MOLECULAR-CLONING; TRANSGENIC MICE; EXPRESSION; MOUSE; PROTEIN; BONE; MUSCLE; CELLS; CDNA; STANNIUS
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2005-12-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙