The phosphoprotein StarD10 is overexpressed in breast cancer and cooperates with ErbB receptors in cellular transformation
- Author(s)
- Olayioye, MA; Hoffmann, P; Pomorski, T; Armes, J; Simpson, RJ; Kemp, BE; Lindeman, GJ; Visvader, JE;
- Details
- Publication Year 2004-05-15,Volume 64,Issue #10,Page 3538-3544
- Journal Title
- CANCER RESEARCH
- Publication Type
- Journal Article
- Abstract
- We have identified that StarD10, a member of the START protein family, is overexpressed in both mouse and human breast tumors. StarD10 was initially discovered on the basis of its cross-reactivity with a phosphoserine-specific antibody in mammary tumors from Neu/ErbB2 transgenic mice and subsequently isolated from SKBR3 human breast carcinoma cells using a multistep biochemical purification strategy. We have shown that StarD10 is capable of binding lipids. StarD10 was found to be overexpressed in 35% of primary breast carcinomas and 64% of human breast cancer cell lines, correlating with their ErbB2/Her2 status. Coexpression of StarD10 with ErbB1/epidermal growth factor receptor in murine fibroblasts enhanced anchorage-independent growth in soft agar, providing evidence for functional cooperation between StarD10 and ErbB receptor signaling. Taken together, these data suggest that overexpression of this lipid-binding protein contributes to breast oncogenesis.
- Publisher
- AMER ASSOC CANCER RESEARCH
- Keywords
- ACUTE REGULATORY PROTEIN; PHOSPHATIDYLCHOLINE TRANSFER PROTEIN; C-SRC; SIGNALING NETWORK; TRANSGENIC MICE; NEU PROTOONCOGENE; MAMMARY-TUMORS; EXPRESSION; ACTIVATION; DOMAIN
- Publisher's Version
- https://doi.org/10.1158/0008-5472.CAN-03-3731
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-05-15 12:00:00