Suppressors of cytokine signalling and regulation of growth hormone action
- Author(s)
- Greenhalgh, CJ; Alexander, WS;
- Details
- Publication Year 2004-06,Volume 14,Issue #3,Page 200-206
- Journal Title
- GROWTH HORMONE & IGF RESEARCH
- Publication Type
- Journal Article
- Abstract
- The Suppressors of Cytokine Signalling (SOCS) are a family of proteins that are produced in response to signals from a diverse range of cytokines and growth factors and which act to attenuate cytokine signal transduction. Members of the SOCS family form a classical negative feedback loop with key actions involving inhibition of the Janus Kinase-Signal Transducers and Activators of Transcription (JAK-STAT) signalling cascade. Extensive analyses have implicated each of CIS, SOCS1, SOCS2 and SOCS3 in the regulation of Growth Hormone (GH) signal transduction. The expression of each of these SOCS proteins is induced in cells stimulated with GH and their over-expression in cell lines blocks aspects of GH signalling. In vivo studies with genetically modified mice have confirmed important physiological roles for SOCS proteins in regulation of GH action. In particular, mice lacking SOCS2 display gigantism accompanied by evidence of deregulated GH signalling. A precise understanding of the actions of SOCS proteins in GH signalling may offer new opportunities for therapeutic intervention in growth disorders and other conditions involving GH action. (C) 2004 Elsevier Ltd. All rights reserved.
- Publisher
- CHURCHILL LIVINGSTONE
- Keywords
- MICE LACKING SUPPRESSOR; SOCS-BOX MOTIF; T-CELLS; TRANSGENIC MICE; GENE-EXPRESSION; DEFICIENT MICE; PROTEIN CIS; FACTOR-I; RECEPTOR; INSULIN
- Publisher's Version
- https://doi.org/10.1016/j.ghir.2003.12.011
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-06-01 12:00:00