Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
- Author(s)
- Belz, GT; Smith, CM; Kleinert, L; Reading, P; Brooks, A; Shortman, K; Carbone, FR; Heath, WR;
- Details
- Publication Year 2004-06-08,Volume 101,Issue #23,Page 8670-8675
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- HERPES-SIMPLEX-VIRUS; LYMPH-NODES; T-CELLS; SURFACE PHENOTYPE; LANGERHANS CELLS; CD8 EXPRESSION; MOUSE THYMUS; CUTTING EDGE; IMMUNITY; RECOGNITION
- Publisher's Version
- https://doi.org/10.1073/pnas.0402644101
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-06-08 12:00:00