Spatial patterns of gene expression in the olfactory bulb

Author(s): Lin, DM; Yang, YH; Scolnick, JA; Brunet, LJ; Marsh, H; Peng, V; Okazaki, Y; Hayashizaki, Y; Speed, TP; Ngai, J;
Details: Publication Year 2004-08-24,Volume 101,Issue #34,Page 12718-12723
Journal Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type: Journal Article
Abstract: How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfactory bulb has been extremely difficult, however, hindering a molecular analysis of convergence. Here, we describe several such genes that have been identified in a screen that compiled microarray data to create a three-dimensional model of gene expression within the mouse olfactory bulb. The expression patterns of these identified genes form the basis of a nascent spatial map of differential gene expression in the bulb.
Publisher: NATL ACAD SCIENCES
Keywords: EXTRACELLULAR-MATRIX MOLECULES; CDNA MICROARRAY DATA; DIFFERENTIAL EXPRESSION; RECEPTORS; GUIDANCE; ORGANIZATION; CONNECTIONS; PATHWAY; SYSTEM; GROWTH
Publisher's Version: https://doi.org/10.1073/pnas.0404872101
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2004-08-24 12:00:00