Divide and conquer: the importance of cell division in regulating B-cell responses
- Author(s)
- Tangye, SG; Hodgkin, PD;
- Details
- Publication Year 2004-08,Volume 112,Issue #4,Page 509-520
- Journal Title
- IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Proliferation is an essential characteristic of clonal selection and is required for the expansion of antigen reactive clones leading to the development of antibody of different isotypes and memory cells. New data for mouse and human B cells point to an important role for division in regulating isotype class and in optimizing development of protective immunity by the regulated entry of cells to the plasma cell lineage.
- Publisher
- BLACKWELL PUBLISHING LTD
- Keywords
- IMMUNOGLOBULIN-SECRETING CELLS; VARIABLE REGION GENES; PLASMA-CELLS; CD40 LIGAND; GERMINAL CENTER; GROWTH-FACTOR; BONE-MARROW; T-CELLS; SOMATIC MUTATION; MOLECULAR CHARACTERIZATION
- Publisher's Version
- https://doi.org/10.1111/j.1365-2567.2004.01950.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-08-01 12:00:00