The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappa B-dependent c-myc expression
- Author(s)
- Grumont, R; Lock, P; Mollinari, M; Shannon, FM; Moore, A; Gerondakis, S;
- Details
- Publication Year 2004-07,Volume 21,Issue #1,Page 19-30
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-kappaB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires c-Rel and ReIA and that blocking this growth by inhibiting protein kinase C theta (PKCtheta) coincides with a failure to upregulate c-myc due to impaired ReIA nuclear import and inhibition of NFAT-dependent c-rel transcription. These results demonstrate that different Rel/NF-kappa dimers regulate the mitogenic growth of mature T and B cells, with a signaling pathway incorporating PKCtheta and NFAT controlling c-Rel/ReIA-induced c-myc expression in activated T cells.
- Publisher
- CELL PRESS
- Keywords
- COLONY-STIMULATING FACTOR; TRANSCRIPTION FACTORS; NUCLEAR-FACTOR; LYMPHOCYTE-PROLIFERATION; EXHIBIT DEFECTS; APOPTOSIS; PROTEINS; PROMOTER; GROWTH; THETA
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2004.06.004
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-07-01 12:00:00