CD45: direct and indirect government of immune regulation
- Author(s)
- Huntington, ND; Tarlinton, DM;
- Details
- Publication Year 2004-07-15,Volume 94,Issue #3,Page 167-174
- Journal Title
- IMMUNOLOGY LETTERS
- Publication Type
- Journal Article
- Abstract
- The protein tyrosine phosphatase (PTP) CD45 is abundantly expressed on all nucleated hematopoietic cells and is critical for classical antigen receptor signalling indicated by the arrested development of B and T cells in mice deficient for CD45. Despite its clear role in positive regulation of signalling through the activation of the Src family of tyrosine kinases, many reports have shown CD45 to also negatively regulate this process. Given such a dichotomy in CD45 function and a poor understanding of the mechanism underlying the phenotype of CD45(-/-) lymphocytes, we considered it timely to review the existing data and attempt to determine whether aspects of the CD45(-/-) phenotype result from excessive positive or negative kinase activity and the target molecules that may mediate such effects. (C) 2004 Elsevier B.V. All tights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- CELL ANTIGEN RECEPTOR; LEUKOCYTE-COMMON ANTIGEN; SRC-FAMILY KINASES; PHOSPHATASE-DEFICIENT MICE; LYN TYROSINE KINASE; HUMAN B-CELLS; T-CELL; THYMOCYTE DEVELOPMENT; CD45-DEFICIENT MICE; NEGATIVE REGULATION
- Publisher's Version
- https://doi.org/10.1016/j.imlet.2004.05.01
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-07-15 12:00:00