DCs as targets for vaccine design
- Author(s)
- Belz, GT; Smith, CM; Bharadwaj, M; Rice, AM; Jackson, DC;
- Details
- Publication Year 2004-04,Volume 6,Issue #2,Page 88-98
- Journal Title
- CYTOTHERAPY
- Publication Type
- Journal Article
- Abstract
- The increasingly stringent requirements laid down by regulatory authorities have brought to an end the largely empirical design of vaccines. Vaccines must now be designed rationally, in order that appropriate immune responses are elicited with few or no side effects. The DC plays a pivotal role in determining the type of immune response that ensues following exposure of the host to an Ag. In this review, we identify some of the features and properties of DCs, and how these properties can be exploited in the design of smart vaccines.
- Publisher
- TAYLOR & FRANCIS AS
- Keywords
- EPIDERMAL LANGERHANS CELLS; REGULATORY DENDRITIC CELLS; ANTIGEN-PRESENTING CELLS; T-CELLS; CUTTING EDGE; IMMUNE-RESPONSE; CROSS-PRESENTATION; SOLUBLE-ANTIGEN; IN-VITRO; RECEPTOR DEC-205
- Publisher's Version
- https://doi.org/10.1080/14653240410005276
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-04-01 12:00:00