Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation
Details
Publication Year 2004-01, Volume 5, Issue #1, Page 55-63
Journal Title
NATURE IMMUNOLOGY
Publication Type
Journal Article
Abstract
Naive B lymphocytes undergo isotype switching and develop into immunoglobulin-secreting cells to generate the appropriate class and amount of antibody necessary for effective immunity. Although this seems complex, we report here that the generation of immunoglobulin G-secreting cells from naive precursors is highly predictable. The probabilities of isotype switching and development into secreting cells change with successive cell divisions and interleave independently. Cytokines alter the probability of each differentiation event, while leaving intact their independent assortment. As a result, cellular heterogeneity arises automatically as the cells divide. Stochastic division-linked regulation of heterogeneity challenges the conventional paradigms linking distinct phenotypes to unique combinations of signals and has the potential to simplify our concept of immune complexity considerably.
Publisher
NATURE PUBLISHING GROUP
Keywords
PRIMARY IMMUNE-RESPONSE; LIVED PLASMA-CELLS; DIACETATE SUCCINIMIDYL ESTER; ANTIBODY-FORMING-CELLS; MEMORY B-CELLS; CD40 LIGAND; IN-SITU; DIVISION; PROLIFERATION; SURVIVAL
Publisher's Version
https://doi.org/10.1038/ni1016
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2004-01-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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