Mucosal immunity - Overcoming the barrier for induction of proximal responses
- Author(s)
- McKenzie, BS; Brady, JL; Lew, AM;
- Details
- Publication Year 2004,Volume 30,Issue #1,Page 35-71
- Journal Title
- IMMUNOLOGIC RESEARCH
- Publication Type
- Journal Article
- Abstract
- Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucosa is often considered the first, and sometimes only, line of defense Therefore, responses that protect the local mucosa are vital. In this review, we first explore the immunological mechanisms that protect the mucosa. We then review the literature of mucosal vaccines within the principles of antigenic composition, dose, and danger, highlighting the need and niche for the next generation of mucosal vaccines.
- Publisher
- HUMANA PRESS INC
- Keywords
- VIRUS-LIKE PARTICLES; HERPES-SIMPLEX-VIRUS; CYTOTOXIC T-LYMPHOCYTE; HIGH ENDOTHELIAL VENULES; INFLUENZA-A VIRUS; RESPIRATORY SYNCYTIAL VIRUS; CELL-ADHESION MOLECULE-1; HEAT-LABILE ENTEROTOXIN; OUTER-MEMBRANE PROTEIN; SECRETORY IMMUNOGLOBULIN-A
- Publisher's Version
- https://doi.org/10.1385/IR:30:1:035
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-01-01 12:00:00