Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase
- Author(s)
- Watson, KG; Cameron, R; Fenton, RJ; Gower, D; Hamilton, S; Jin, B; Krippner, GY; Luttick, A; McConnell, D; MacDonald, SJF; Mason, AM; Nguyen, V; Tucker, SP; Wu, WY;
- Details
- Publication Year 2004-03-22,Volume 14,Issue #6,Page 1589-1592
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Publication Type
- Journal Article
- Abstract
- A set of trimeric and tetrameric derivatives 6-11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discrete multimeric compounds are all significantly more antiviral than zanamivir and also show outstanding long-lasting protective activity when tested in mouse influenza infectivity experiments. (C) 2004 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- CONJUGATED DENDRITIC POLYMERS; ZANAMIVIR
- Publisher's Version
- https://doi.org/10.1016/j.bmcl.2003.09.102
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-03-22 12:00:00