Cutting edge: Conventional CD8 alpha(+) dendritic cells are generally involved in priming CTL immunity to viruses
- Author(s)
- Belz, GT; Smith, CM; Eichner, D; Shortman, K; Karupiah, G; Carbone, FR; Heath, WK;
- Details
- Publication Year 2004-02-15,Volume 172,Issue #4,Page 1996-2000
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding bow different DC subsets contribute to immunity to different-pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- HERPES-SIMPLEX-VIRUS; CD8(+) T-CELLS; LYMPH-NODES; IN-VIVO; ANTIGEN PRESENTATION; SURFACE PHENOTYPE; TRANSGENIC MOUSE; LANGERHANS CELLS; POPULATIONS; EXPRESSION
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- Refer to copyright notice on published article.
Creation Date: 2004-02-15 12:00:00