Apoptosis in the development and treatment of cancer
- Details
- Publication Year 2005-02,Volume 26,Issue #2,Page 263-270
- Journal Title
- CARCINOGENESIS
- Publication Type
- Journal Article
- Abstract
- Our somatic cells are born by mitosis and almost all will die by apoptosis, a physiological process of cellular suicide. Cancers can occur when this balance is disturbed, either by an increase in cell proliferation or a decrease in cell death. The goal of cancer therapy is to promote the death of cancer cells without causing too much damage to normal cells. Our knowledge of the mechanisms of apoptosis has enhanced our understanding of how some cancers originate and progress. It has also revealed that existing cancer therapies can work in two ways, by induction of apoptosis as well as by direct toxicity. In some cases resistance to apoptosis may explain why cancer therapies fail. Novel treatments designed to exploit our knowledge of apoptotic mechanisms are under development to promote apoptosis of cancer cells and limit concurrent death of normal cells.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- PROGRAMMED CELL-DEATH; SMALL-MOLECULE ANTAGONISTS; MYC-INDUCED APOPTOSIS; BCL-2 FAMILY; C-MYC; TRANSGENIC MICE; MALT LYMPHOMA; CHEMOTHERAPEUTIC-AGENTS; PROAPOPTOTIC ACTIVITY; BH3-ONLY PROTEINS
- Publisher's Version
- https://doi.org/10.1093/carcin/bgh283
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-02-01 12:00:00