The role of BH3-only proteins in the immune system
- Author(s)
- Strasser, A;
- Details
- Publication Year 2005-03,Volume 5,Issue #3,Page 189-200
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Programmed cell death - also known as apoptosis - has a crucial role in the immune system of mammals and other animals. It removes useless cells and potentially dangerous cells, including lymphocytes, and is involved in killing pathogen-infected or damaged cells. Defects in this process have been found to cause or contribute to diseases of the immune system, including immunodeficiency, autoimmunity, lymphoma and leukaemia. This review describes BH3-only proteins, a pro-apoptotic subgroup of the BCL-2 family, and their role in the development and function of the immune system.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- BCL-2 FAMILY-MEMBER; CYTOCHROME-C RELEASE; RECEPTOR-DEFICIENT MICE; T-CELL DEATH; SURVIVAL-PROMOTING PROTEINS; BAX-DEPENDENT APOPTOSIS; NEGATIVE SELECTION; CASPASE ACTIVATION; TRANSGENIC MICE; X-L
- Publisher's Version
- https://doi.org/10.1038/nri1568
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-03-01 12:00:00