Synthesis of new beta-amino acids via 5-oxazolidinones and the Arndt-Eistert procedure
- Author(s)
- Hughes, AB; Sleebs, BE;
- Details
- Publication Year 2005,Volume 58,Issue #11,Page 778-784
- Journal Title
- AUSTRALIAN JOURNAL OF CHEMISTRY
- Publication Type
- Journal Article
- Abstract
- N-Methyl beta-amino acids are potentially useful amino acid derivatives for incorporation in lead peptide therapeutics. The syntheses of five such compounds are presented. Their synthesis via 6-oxazinanones was low yielding. Alternatively, reductive cleavage of a 5-oxazolidinone gave the N-methyl alpha-amino acid, which was then homologated via an Arndt-Eistert procedure in high yield to give the N-methyl beta-amino acid.
- Publisher
- C S I R O PUBLISHING
- Keywords
- DIAZOKETONES; ANHYDRIDES
- Publisher's Version
- https://doi.org/10.1071/CH05199
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-01-01 12:00:00