Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1)arthritis

Wong, PKK; Campbell, IK; Robb, L; Wicks, IP

Author(s): Wong, PKK; Campbell, IK; Robb, L; Wicks, IP;
Details: Publication Year 2005-01-21,Volume 29,Issue #2,Page 72-76
Journal Title: CYTOKINE
Publication Type: Journal Article
Abstract: Objective: To evaluate the role of interleukin-11 (IL-11d) in acute mBSA/IL-1-induced inflammatory arthritis. Methods: IL-11 was administered via intra-articular (IA) injection into knee joints of C57BL/6 mice and joint histology was assessed. The mitogenic response to IL-11 was measured in wild-type (WT) synovial fibroblasts. IL-1 was used as a comparator in both the studies. The severity of acute methylated bovine serum albumin (mBSA)/IL-1 arthritis was determined in WT and IL-11 receptor null (IL-11Ra1(-/-)) mice. In parallel experiments, a neutralising antibody to IL-11 was administered to WT mice throughout this model. Results: IA injections of IL-11 resulted in mild-to-moderate joint inflammation which was less than that due to IA IL-1. IL-11 had a dose-dependent mitogenic effect on WT synovial fibroblasts (P < 0.01). mBSA/IL-1 acute arthritis was reduced in IL-11 Ra1(-/-) versus WT mice (histological arthritis score: 10.1 +/- 0.5 versus 12.8 +/- 0.7, respectively; P = 0.01). Administration of an IL-11 neutralising antibody to WT mice reduced mBSA/IL-1 acute arthritis scores compared to control antibody (10.6 +/- 0.7 versus 13.3 +/- 0.6, respectively; P = 0.02). Conclusions: These data demonstrate that endogenous IL-11 exerts relatively mild but consistent pro-inflammatory effects in acute inflammatory arthritis. (C) 2004 Elsevier Ltd. All rights reserved.
Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Keywords: COLLAGEN-INDUCED ARTHRITIS; RHEUMATOID-ARTHRITIS; INTERLEUKIN-11 PRODUCTION; RECEPTOR; EXPRESSION; CARTILAGE; CELLS; MICE
Publisher's Version: https://doi.org/10.1016/j.cyto.2004.09.011
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2005-01-21 12:00:00