T-lymphocyte death during shutdown of an immune response

Author(s): Strasser, A; Pellegrini, M;
Details: Publication Year 2004-11,Volume 25,Issue #11,Page 610-615
Journal Title: TRENDS IN IMMUNOLOGY
Publication Type: Journal Article
Abstract: The immune system serves to protect organisms from infectious pathogens. During infection, lymphocytes and cells of the innate immune system, expressing receptors that recognize foreign antigens, proliferate and differentiate to develop effector functions that help to kill the pathogens. Effector functions, such as cellular or antibody mediated cytotoxicity, and inflammatory cytokines can be harmful to the host. To limit damage to healthy tissue, mechanisms have evolved to shut down immune responses, including cell inactivation and cell death. Here we discuss recent studies demonstrating that the death of antigen-activated T lymphocytes during termination of an immune response is initiated by the BH3-only Bcl-2 family member Bim and also requires its multi-BH domain pro-apoptotic relatives Bax and Bak.
Publisher: ELSEVIER SCI LTD
Keywords: BCL-2 FAMILY-MEMBER; RECEPTOR TRANSGENIC MICE; BH3-ONLY PROTEINS; CELL-DEATH; IN-VIVO; APOPTOTIC RESPONSES; CASPASE ACTIVATION; DEFICIENT MICE; MOTOR COMPLEX; BIM
Publisher's Version: https://doi.org/10.1016/j.it.2004.08.012
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2004-11-01 12:00:00