Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity
- Author(s)
- Smith, CM; Wilson, NS; Waithman, J; Villadangos, JA; Carbone, FR; Heath, WR; Belz, GT;
- Details
- Publication Year 2004-11,Volume 5,Issue #11,Page 1143-1148
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- HERPES-SIMPLEX-VIRUS; CUTTING EDGE; LYMPH-NODES; CD8-T-CELL MEMORY; CD40 EXPRESSION; CD4-T-CELL HELP; ACUTE INFECTION; GENERATION; RESPONSES; INVIVO
- Publisher's Version
- https://doi.org/10.1038/ni1129
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-11-01 12:00:00