Gastrula organiser and embryonic patterning in the mouse
- Details
- Publication Year 2004-10,Volume 15,Issue #5,Page 543-554
- Journal Title
- SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Embryonic patterning of the mouse during gastrulation and early organogenesis engenders the specification of anterior versus posterior structures and body laterality by the interaction of signalling and modulating activities. A group of cells in the mouse gastrula, characterised by the expression of a repertoire of "organiser" genes, acts as a source and the conduit for allocation of the axial mesoderm, floor plate and definitive endoderm. The organiser and its derivatives provide the antagonistic activity that modulates WNT and TGFbeta signalling. Recent findings show that the organiser activity is augmented by morphogenetic activity of the extraembryonic and embryonic endoderm, suggesting embryonic patterning is not solely the function of the organiser. (C) 2004 Elsevier Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
- Keywords
- LEFT-RIGHT ASYMMETRY; ANTERIOR VISCERAL ENDODERM; CERBERUS-RELATED GENE; GERM LAYER FORMATION; PRIMITIVE STREAK; NODAL EXPRESSION; HEAD INDUCTION; NEURAL INDUCTION; CELL MOVEMENTS; BODY PLAN
- Publisher's Version
- https://doi.org/10.1016/j.semcdb.2004.04.005
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-10-01 12:00:00