The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in the Gambia
- Author(s)
- Corran, PH; O'Donnell, RA; Todd, J; Uthaipibull, C; Holder, AA; Crabb, BS; Riley, EM;
- Details
- Publication Year 2004-10,Volume 72,Issue #10,Page 6185-6189
- Journal Title
- INFECTION AND IMMUNITY
- Publication Type
- Journal Article
- Abstract
- In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of greater than or equal to1,000 parasites/mul than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- C-TERMINAL FRAGMENT; PLASMODIUM-FALCIPARUM; SERUM ANTIBODIES; IMMUNE-RESPONSE; AOTUS MONKEYS; CLINICAL IMMUNITY; ANTIGEN; PROTECTION; EPITOPES; VACCINE
- Publisher's Version
- https://doi.org/10.1128/IAI.72.10.6185-6189.2004
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- Refer to copyright notice on published article.
Creation Date: 2004-10-01 12:00:00