Targeting malaria virulence and remodeling proteins to the host erythrocyte
- Author(s)
- Marti, M; Good, RT; Rug, M; Knuepfer, E; Cowman, AF;
- Details
- Publication Year 2004-12-10,Volume 306,Issue #5703,Page 1930-1933
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to similar to8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- FALCIPARUM-INFECTED ERYTHROCYTES; PLASMODIUM-FALCIPARUM; ANTIGENIC VARIATION; GENOME SEQUENCE; LIFE-CYCLE; EXPRESSION; TRAFFICKING; SURFACE; GENES
- Publisher's Version
- https://doi.org/10.1126/science.1102452
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-12-10 12:00:00