Targeting malaria virulence and remodeling proteins to the host erythrocyte
Details
Publication Year 2004-12-10,Volume 306,Issue #5703,Page 1930-1933
Journal Title
SCIENCE
Publication Type
Journal Article
Abstract
To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to similar to8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Keywords
FALCIPARUM-INFECTED ERYTHROCYTES; PLASMODIUM-FALCIPARUM; ANTIGENIC VARIATION; GENOME SEQUENCE; LIFE-CYCLE; EXPRESSION; TRAFFICKING; SURFACE; GENES
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2004-12-10 12:00:00
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