Principles of immunological tolerance
- Author(s)
- Miller, JFAP;
- Details
- Publication Year 2005,Volume 32,Issue #6,Page 322-331
- Journal Title
- TRANSFUSION MEDICINE AND HEMOTHERAPY
- Publication Type
- Journal Article
- Abstract
- Tolerance of T and B lymphocytes to self-antigens is achieved at various levels in the primary lymphoid organs - the thymus and the bone marrow - and in the periphery. It can be induced by many different cell-intrinsic or cell-extrinsic mechanisms. The former act directly on the responding cell and include deletion, receptor editing, and functional silencing. The latter require some input from other cell types such as dendritic cells and regulatory T cells. Defects at any of those levels can lead to autoimmune disease.
- Publisher
- KARGER
- Keywords
- REGULATORY T-CELLS; REACTIVE LYMPHOCYTES-B; CD8-ALPHA(+) DENDRITIC CELLS; SELF-TOLERANCE; IN-VIVO; PERIPHERAL DELETION; NEONATAL THYMECTOMY; V(D)J RECOMBINATION; NEGATIVE SELECTION; INSULIN EXPRESSION
- Publisher's Version
- https://doi.org/10.1159/000089119
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-01-01 12:00:00