Coevolution of the relaxin-like peptides and their receptors
- Author(s)
- Wilkinson, TN; Speed, TP; Tregear, GW; Bathgate, RAD;
- Journal Title
- RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE
- Publication Type
- S
- Abstract
- Currently, four relaxin peptide family receptors are known: LGR7 is the relaxin receptor, although it also interacts specifically with relaxin-3; LGR8 is the insulin-like factor 3 (INSL3) receptor; and GPCR135 or the somatostatin- and angiotensin-like peptide receptor (SALPR) and GPCR142 are both specific relaxin-3 receptors. Because these receptors coevolved together with their relaxin ligands, phylogenetic analysis of these sequences can provide insight into peptide-receptor interactions and even predict interacting partners for INSL4, INSL5, and INSL6, the receptors for which are unknown.
- Publisher
- NEW YORK ACAD SCIENCES
- Keywords
- IDENTIFICATION; GPCR142; FAMILY
- Publisher's Version
- https://doi.org/10.1196/annals.1282.080
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2005-01-01 12:00:00