Clinical features and pathogenesis of severe malaria
- Author(s)
- Mackintosh, CL; Beeson, JG; Marsh, K;
- Details
- Publication Year 2004-12,Volume 20,Issue #12,Page 597-603
- Journal Title
- TRENDS IN PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- A major change in recent years has been the recognition that severe malaria, predominantly caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a range of clinical features. It is becoming apparent that syndromes such as cerebral malaria, which were previously considered relatively clear cut, are not homogenous conditions with a single pathological correlate or pathogenic process. This creates challenges both for elucidating key mechanisms of disease and for identifying suitable targets for adjunctive therapy. The development of severe malaria probably results from a combination of parasite-specific factors, such as adhesion and sequestration in the vasculature and the release of bioactive molecules, together with host inflammatory responses. These include cytokine and chemokine production and cellular infiltrates. This review summarizes progress in several areas presented at a recent meeting.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- FALCIPARUM-INFECTED ERYTHROCYTES; MURINE CEREBRAL MALARIA; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE PRODUCTION; CHONDROITIN SULFATE-A; INTERCELLULAR-ADHESION MOLECULE-1; PLASMODIUM-FALCIPARUM; CEREBROSPINAL-FLUID; AFRICAN CHILDREN; DISEASE SEVERITY
- Publisher's Version
- https://doi.org/10.1016/j.pt.2004.09.006
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-12-01 12:00:00