Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
- Author(s)
- Carbone, FR; Belz, GT; Heath, WR;
- Details
- Publication Year 2004-12,Volume 25,Issue #12,Page 655-658
- Journal Title
- TRENDS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- CD8-ALPHA(+) DENDRITIC CELLS; COMMON PRECURSOR POPULATION; IN-VIVO; LANGERHANS CELLS; STEADY-STATE; EFFICIENT PRESENTATION; CUTTING EDGE; MATURATION; DEC-205; MOUSE
- Publisher's Version
- https://doi.org/10.1016/j.it.2004.09.013
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-12-01 12:00:00