Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim
- Author(s)
- Liston, A; Lesage, S; Gray, DHD; O'Reilly, LA; Strasser, A; Fahrer, AM; Boyd, RL; Wilson, J; Baxter, AG; Gallo, EM; Crabtree, GR; Peng, KM; Wilson, SR; Goodnow, CC;
- Details
- Publication Year 2004-12,Volume 21,Issue #6,Page 817-830
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7,rnit101, and D15mit229 which cause a generalized resistance to thymic deletion in vivo that applies equally to Aire-induced organ-specific gene products in the thymic medulla and to systemic antigens expressed at high levels throughout the thymus and affects CD4(+).
- Publisher
- CELL PRESS
- Keywords
- NONOBESE DIABETIC MICE; ORGAN-SPECIFIC AUTOIMMUNITY; FAMILY-MEMBER BIM; CD4(+) T-CELLS; NEGATIVE SELECTION; B-CELLS; GENETIC-CONTROL; PROTEIN BIM; APOPTOSIS; SELF
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2004.10.014
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2004-12-01 12:00:00