Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim
Details
Publication Year 2004-12, Volume 21, Issue #6, Page 817-830
Journal Title
IMMUNITY
Publication Type
Journal Article
Abstract
The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7,rnit101, and D15mit229 which cause a generalized resistance to thymic deletion in vivo that applies equally to Aire-induced organ-specific gene products in the thymic medulla and to systemic antigens expressed at high levels throughout the thymus and affects CD4(+).
Publisher
CELL PRESS
Keywords
NONOBESE DIABETIC MICE; ORGAN-SPECIFIC AUTOIMMUNITY; FAMILY-MEMBER BIM; CD4(+) T-CELLS; NEGATIVE SELECTION; B-CELLS; GENETIC-CONTROL; PROTEIN BIM; APOPTOSIS; SELF
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2004-12-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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