Concepts for the development of a quantitative theory of clonal selection and class regulation using lessons from the original
- Author(s)
- Hodgkin, PD;
- Details
- Publication Year 2008-02,Volume 86,Issue #2,Page 161-165
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- When Burnet wrote his modification of Jerne's theory he simply wrote- It is postulated that when antigen-(receptor) contact takes place on the surface of a lymphocyte the cell is activated to settle in an appropriate tissue... and there undergo proliferation to produce a variety of descendants'.(1) But studies of 'activation' and 'proliferation' following receptor contact have turned out to be surprisingly complex-much more complex than the theory apparently requires. It is timely, on this 50th anniversary, to take a closer look at the complexity and highlight some lesser-known general features of the clonal selection theory and of B cell activation that can be useful in formulating a quantitative version of this theory that includes class regulation and cellular heterogeneity.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- DIVISION; DIFFERENTIATION; CELLS
- Publisher's Version
- https://doi.org/10.1038/sj.icb.7100164
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-02-01 12:00:00
Last Modified: 2015-10-29 03:05:00