Dendritic cell-induced memory T cell activation in nonlymphoid tissues
- Author(s)
- Wakim, LM; Waithman, J; van Rooijen, N; Heath, WR; Carbone, FR;
- Details
- Publication Year 2008-01-11,Volume 319,Issue #5860,Page 198-202
- Journal Title
- SCIENCE
- Publication Type
- Journal Article
- Abstract
- Secondary lymphoid organs are dominant sites of T cell activation, although many T cells are subsequently retained within peripheral tissues. Currently, these nonlymphoid compartments are viewed as sites only of effector T cell function, without the involvement of renewed induction of immunity via the interactions with professional antigen- presenting cells. We describe a method of reactivation of herpes simplex virus to examine the stimulation of tissue- resident T cells during secondary challenge. The results revealed that memory CD8(+) T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4(+) T cells and recruited dendritic cells. These findings lend evidence for the existence of a sophisticated T cell response mechanism in extra- lymphoid tissues that can act to control localized infection.
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Keywords
- HERPES-SIMPLEX-VIRUS; IN-VIVO; SENSORY GANGLIA; LYMPH-NODE; INFECTIONS; MONOCYTES; TYPE-1; DIFFERENTIATION; GENERATION; RESPONSES
- Publisher's Version
- https://doi.org/10.1126/science.1151869
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-01-11 12:00:00