The regulation of the B-cell gene expression programme by Pax5
- Author(s)
- Holmes, ML; Pridans, C; Nutt, SL;
- Details
- Publication Year 2008-01,Volume 86,Issue #1,Page 47-53
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The activity of the transcription factor paired box gene 5 (Pax5) is essential for many aspects of B lymphopoiesis including the initial commitment to the lineage, immunoglobulin rearrangement, pre-B cell receptor signalling and maintaining cell identity in mature B cells. Deregulated or reduced Pax5 activity has also been implicated in B-cell malignancies both in human disease and mouse models. Candidate gene approaches and biochemical analysis have revealed that Pax5 regulates B lymphopoiesis by concurrently activating B cell-specific gene expression as well as repressing the expression of genes, many of which are associated with non-B cell lineages. These studies have been recently complemented with more exhaustive microarray studies, which have identified and validated a large panel of Pax5 target genes. These target genes reveal a gene regulatory network, with Pax5 at its centre that controls the B-cell gene expression programme.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- TRANSCRIPTION FACTOR PAX5; IN-VIVO; CHAIN GENE; HEMATOPOIETIC PROGENITOR; INTERLEUKIN-7 RECEPTOR; LYMPHOID PROGENITOR; LINEAGE COMMITMENT; ACTIVATOR PROTEIN; BINDING PROTEINS; REPORTER GENE
- Publisher's Version
- https://doi.org/10.1038/sj.icb.7100134
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-01-01 12:00:00