Stat5 as a diagnostic marker for leukemia
- Details
- Publication Year 2008-01,Volume 8,Issue #1,Page 73-82
- Journal Title
- EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Publication Type
- Journal Article
- Abstract
- The Jak-Stat-Socs pathway is an important component of cytokine receptor signaling. Not surprisingly, perturbation of this pathway is implicated in diseases of hernatopoietic and immune origin, including leukemia, lymphoma and immune deficiencies. This review examines the role of a key component of this pathway, Stat5. This has been shown to be activated in a variety of leukemias and myeloproliferative disorders, including downstream of a range of key oncogenes where it has been shown to play an important role in mediating their effects. Therefore, Stat5 represents a useful pan-leukemia/myeloproliferative disorder diagnostic marker and key therapeutic end point, as well as representing an attractive therapeutic target for these disorders.
- Publisher
- EXPERT REVIEWS
- Keywords
- CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; ABL TYROSINE KINASE; T-CELL LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; RETINOIC ACID RECEPTOR; JAK2 V617F MUTATION; BCR-ABL; CONSTITUTIVE ACTIVATION
- Publisher's Version
- https://doi.org/10.1586/14737159.8.1.73
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-01-01 12:00:00