Minimal activation of memory CD8+T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+T cells
- Author(s)
- Belz, GT; Bedoui, S; Kupresanin, F; Carbone, FR; Heath, WR;
- Details
- Publication Year 2007-10,Volume 8,Issue #10,Page 1060-1066
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Of the many dendritic cell (DC) subsets, DCs expressing the monomorphic coreceptor CD8 alpha-chain (CD8 alpha) are localized permanently in lymphoid organs, whereas 'tissue-derived DCs' remain in nonlymphoid tissues until they 'capture' antigen and then move to local lymph nodes. Here we show that after lung infection, both naive and memory CD8(+) 'killer' T cells responded to influenza virus antigens presented by lymph node-resident CD8 alpha(+) DCs, but only naive cells responded to antigens presented by lung-derived DCs. This difference provides a mechanism for priming naive T cell responses in conditions in which robust memory predominates. Our findings have implications for immunity to pathogens that can mutate their T cell epitopes, such as influenza virus and human immunodeficiency virus, and challenge the long-held view that memory T cells have less-stringent requirements for activation than naive T cells have.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- CD8(+) T-CELLS; ORIGINAL ANTIGENIC SIN; HERPES-SIMPLEX-VIRUS; INFLUENZA-A VIRUS; IN-VIVO DEPLETION; CUTTING EDGE; LANGERHANS CELLS; IMMUNITY; INFECTION; ESCAPE
- Publisher's Version
- https://doi.org/10.1038/ni1505
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-10-01 12:00:00