Skin-derived dendritic cells can mediate deletional tolerance of class I-Restricted self-reactive T cells
- Author(s)
- Waithman, J; Allan, RS; Kosaka, H; Azukizawa, H; Shortman, K; Lutz, MB; Heath, WR; Carbone, FR; Belz, GT;
- Details
- Publication Year 2007-10-01,Volume 179,Issue #7,Page 4535-4541
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Skin-draining lymph nodes contain a number of dendritic cell (DC) subsets of different origins. Some of these are migratory, such as the skin-derived epidermal Langerhans cells and a separate dermal DC subset, whereas others are lymphoid resident in nature, such as the CD8(+) DCs found throughout the lymphoid tissues. In this study, we examine the DC subset presentation of skin-derived self-Ag by migratory and lymphoid-resident DCs, both in the steady state and under conditions of local skin infection. We show that presentation of self-Ag is confined to skin-derived migrating DCs in both settings. Steady state presentation resulted in deletional T cell tolerance despite these DCs expressing a relatively mature phenotype as measured by traditional markers such as the level of MHC class II and CD86 expression. Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- HERPES-SIMPLEX-VIRUS; LANGERHANS CELLS; CROSS-PRESENTATION; LYMPH-NODES; CONTACT HYPERSENSITIVITY; PERIPHERAL DELETION; STEADY-STATE; LIFE-SPAN; MOUSE; IMMUNITY
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- Refer to copyright notice on published article.
Creation Date: 2007-10-01 12:00:00