The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease
- Author(s)
- Henderson, KN; Reid, HH; Borg, NA; Broughton, SE; Huyton, T; Anderson, RP; McCluskey, J; Rossjohn, J;
- Journal Title
- ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
- Publication Type
- Journal Article
- Abstract
- The major histocompatibility complex (MHC) class II molecules HLA-DQ2 and HLA-DQ8 are key risk factors in coeliac disease, as they bind deamidated gluten peptides that are subsequently recognized by CD4+ T cells. Here, the production and crystallization of both HLA-DQ2 and HLA-DQ8 in complex with the deamidated gliadin peptides DQ2 alpha-I (PQPELPYPQ) and DQ8 alpha-I (EGSFQPSQE), respectively, are reported.
- Publisher
- BLACKWELL PUBLISHING
- Keywords
- MAJOR HISTOCOMPATIBILITY COMPLEX; RAY-DIFFRACTION DATA; T-CELLS; SUSCEPTIBILITY; PREVALENCE; POPULATION; EPITOPES; ICEBERG; GLUTEN
- Publisher's Version
- https://doi.org/10.1107/S1744309107051408
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-12-01 12:00:00