BLIMP1 guides the fate of effector B and T cells
- Author(s)
- Nutt, SL; Fairfax, KA; Kallies, A;
- Details
- Publication Year 2007-12,Volume 7,Issue #12,Page 923-927
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- B-lymphocyte-induced maturation protein 1 (BLIMP1) is a transcriptional repressor, and its importance in controlling the terminal differentiation of antibody-secreting cells (ASCs) is well established. However, as we discuss in this Progress article, it has now become evident that the ASC programme consists of a discrete BLIMP1-independent initiation phase, followed by a second step in which BLIMP1 is absolutely required for the differentiation of fully mature ASCs. In addition, an important role for BLIMP1 in maintaining the homeostasis of effector T cells is emerging, suggesting intriguing parallels between the control of effector-cell fates in both B and T cells.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- TRANSCRIPTIONAL REPRESSOR BLIMP-1; SECRETING PLASMA-CELLS; BONE-MARROW; GERMINAL CENTER; DIFFERENTIATION; EXPRESSION; LYMPHOCYTES; PROTEIN; GENE; MAINTENANCE
- Publisher's Version
- https://doi.org/10.1038/nri2204
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-12-01 12:00:00