Proteomics-driven cancer biomarker discovery: looking to the future
Details
Publication Year 2008-02, Volume 12, Issue #1, Page 72-77
Journal Title
CURRENT OPINION IN CHEMICAL BIOLOGY
Publication Type
Journal Article
Abstract
Availability of a suite of biomarkers; for early detection, stratification into distinct subtypes, and monitoring progression or response to therapy promises significant improvements in clinical outcomes for cancer patients. However, despite the recent progress in proteomics technologies based on mass spectrometry (MS), discovery of novel clinical assessment tools has been slow. This is, partly due to the inherent difficulties in working with blood as the biospecimen for candidate discovery. A better understanding of the limitations of blood for comparative protein profiling and a better appreciation of the advantages of cancer tissue or cancer cell secretomes have the potential to greatly enhance the progress.
Publisher
CURRENT BIOLOGY LTD
Keywords
LASER CAPTURE MICRODISSECTION; DIFFERENTIAL PEPTIDE DISPLAY; LOW ABUNDANCE PROTEINS; GEL-ELECTROPHORESIS; MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; QUANTITATIVE-ANALYSIS; COLORECTAL CANCERS; CONDITIONED MEDIA; FLUORESCENT DYES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-02-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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