SOCS regulation of the JAK/STAT signalling pathway
- Author(s)
- Croker, BA; Kiu, H; Nicholson, SE;
- Details
- Publication Year 2008-08,Volume 19,Issue #4,Page 414-422
- Journal Title
- SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The suppressor of cytokine signalling (SOCS) proteins were, as their name suggests, first described as inhibitors of cytokine signalling. While their actions clearly now extend to other intracellular pathways, they remain key negative regulators of cytokine and growth factor signalling. In this review we focus on the mechanics of SOCS action and the complexities of the mouse models that have underpinned our current understanding of SOCS biology. (C) 2008 Elsevier Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- HUMAN HEPATOCELLULAR-CARCINOMA; PHYSIOLOGICAL NEGATIVE REGULATOR; STIMULATING FACTOR-RECEPTOR; INTERFERON-GAMMA RECEPTOR; KINASE INHIBITORY REGION; MICE LACKING SUPPRESSOR; ACUTE MYELOID-LEUKEMIA; JANUS TYROSINE KINASE; T-CELL LYMPHOMA; CYTOKINE SIGNALING-1
- Publisher's Version
- https://doi.org/10.1016/j.semcdb.2008.07.010
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-08-01 12:00:00