Critical roles for c-Myb in hematopoietic progenitor cells
- Author(s)
- Greig, KT; Carotta, S; Nutt, SL;
- Details
- Publication Year 2008-08,Volume 20,Issue #4,Page 247-256
- Journal Title
- SEMINARS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- While it has long been known that the transcription factor c-Myb is an essential regulator of hematopoiesis, its precise molecular targets have remained elusive. Cell line studies suggest that c-Myb promotes proliferation and at the same time inhibits differentiation, however the early lethality of c-Myb deficient embryos precluded analysis of its role in adult hematopoiesis. Here we review insights derived from recently developed mouse models of c-Myb deficiency that are viable as adults. These studies reveal a complex array of functions for c-Myb in multiple hematopoietic cell types that will redefine our understanding of this crucial transcription factor. (C) 2008 Elsevier Ltd. All rights reserved.
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- NEGATIVE REGULATORY DOMAIN; IMMATURE B-CELLS; T-CELL; TRANSCRIPTION-FACTOR; V-MYB; ONCOGENIC ACTIVATION; DIFFERENTIAL EXPRESSION; CONSTITUTIVE EXPRESSION; MYELOID PROGENITOR; COACTIVATOR P300
- Publisher's Version
- https://doi.org/10.1016/j.smim.2008.05.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-08-01 12:00:00