The nuclear factor-kappa B and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage
Details
Publication Year 2008-07, Volume 6, Issue #7, Page 1193-1203
Journal Title
MOLECULAR CANCER RESEARCH
Publication Type
Journal Article
Abstract
With nuclear factor-kappa B (NF-kappa B) and p53 functions generally having disparate outcomes for cell survival and cell division, understanding how these pathways are coordinated following a common activation signal such as DNA damage has important implications for cancer therapy. Conflicting reports concerning NF-kappa B and p53 interplay in different cell line models prompted a reexamination of this issue using mouse primary thymocytes and embryonic fibroblasts, plus fibroblasts transformed by EMUS. Here, we report that following the treatment of these cells with a range of stress stimuli, p53 and NF-kappa B were found to regulate cell cycling and survival independently.
Publisher
AMER ASSOC CANCER RESEARCH
Keywords
TUMOR-NECROSIS-FACTOR; INDUCED APOPTOSIS; INDUCE APOPTOSIS; BCL-2 EXPRESSION; DNA-DAMAGE; T-CELLS; DEATH; REL; TRANSCRIPTION; ACTIVATION
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-07-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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