The nuclear factor-kappa B and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage
- Author(s)
- Nesic, D; Grurnont, R; Gerondakis, S;
- Details
- Publication Year 2008-07,Volume 6,Issue #7,Page 1193-1203
- Journal Title
- MOLECULAR CANCER RESEARCH
- Publication Type
- Journal Article
- Abstract
- With nuclear factor-kappa B (NF-kappa B) and p53 functions generally having disparate outcomes for cell survival and cell division, understanding how these pathways are coordinated following a common activation signal such as DNA damage has important implications for cancer therapy. Conflicting reports concerning NF-kappa B and p53 interplay in different cell line models prompted a reexamination of this issue using mouse primary thymocytes and embryonic fibroblasts, plus fibroblasts transformed by EMUS. Here, we report that following the treatment of these cells with a range of stress stimuli, p53 and NF-kappa B were found to regulate cell cycling and survival independently.
- Publisher
- AMER ASSOC CANCER RESEARCH
- Keywords
- TUMOR-NECROSIS-FACTOR; INDUCED APOPTOSIS; INDUCE APOPTOSIS; BCL-2 EXPRESSION; DNA-DAMAGE; T-CELLS; DEATH; REL; TRANSCRIPTION; ACTIVATION
- Publisher's Version
- https://doi.org/10.1158/1541-7786.MCR-07-2125
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-07-01 12:00:00