The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
- Loughran, SJ; Kruse, EA; Hacking, DF; de Graaf, CA; Hyland, CD; Willson, TA; Henley, KJ; Ellis, S; Voss, AK; Metcalf, D; Hilton, DJ; Alexander, WS; Kile, BT;
Publication Year 2008-07, Volume 9, Issue #7, Page 810-819
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
- NATURE PUBLISHING GROUP
- ACUTE MYELOID-LEUKEMIA; ETS-RELATED GENE; CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA; GENOME-WIDE; C-MPL; DOWN-SYNDROME; MICE LACKING; MEGAKARYOBLASTIC LEUKEMIA; TARGETED DISRUPTION; PROGENITOR CELLS
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-07-01 12:00:00Last Modified: 0001-01-01 12:00:00