The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
- Author(s)
- Loughran, SJ; Kruse, EA; Hacking, DF; de Graaf, CA; Hyland, CD; Willson, TA; Henley, KJ; Ellis, S; Voss, AK; Metcalf, D; Hilton, DJ; Alexander, WS; Kile, BT;
- Details
- Publication Year 2008-07,Volume 9,Issue #7,Page 810-819
- Journal Title
- NATURE IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- ACUTE MYELOID-LEUKEMIA; ETS-RELATED GENE; CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA; GENOME-WIDE; C-MPL; DOWN-SYNDROME; MICE LACKING; MEGAKARYOBLASTIC LEUKEMIA; TARGETED DISRUPTION; PROGENITOR CELLS
- Publisher's Version
- https://doi.org/10.1038/ni.1617
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-07-01 12:00:00