The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells
Details
Publication Year 2008-07, Volume 9, Issue #7, Page 810-819
Journal Title
NATURE IMMUNOLOGY
Publication Type
Journal Article
Abstract
Ets-related gene (ERG), which encodes a member of the Ets family of transcription factors, is a potent oncogene. Chromosomal rearrangements involving ERG are found in acute myeloid leukemia, acute lymphoblastic leukemia, Ewing's sarcoma and more than half of all prostate cancers; however, the normal physiological function of Erg is unknown. We did a sensitized genetic screen of the mouse for regulators of hematopoietic stem cell function and report here a germline mutation of Erg. We show that Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
Publisher
NATURE PUBLISHING GROUP
Keywords
ACUTE MYELOID-LEUKEMIA; ETS-RELATED GENE; CONGENITAL AMEGAKARYOCYTIC THROMBOCYTOPENIA; GENOME-WIDE; C-MPL; DOWN-SYNDROME; MICE LACKING; MEGAKARYOBLASTIC LEUKEMIA; TARGETED DISRUPTION; PROGENITOR CELLS
Publisher's Version
https://doi.org/10.1038/ni.1617
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-07-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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