Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected
Details
Publication Year 2008-09-15, Volume 52, Issue #4, Page 559-565
Journal Title
TOXICON
Publication Type
Journal Article
Abstract
The platypus, as an egg-laying mammal, displays an unusual mixture of reptilian and mammalian characteristics. It is also venomous, and further investigations into its little-studied venom may lead to the development of novel pharmaceuticals and drug targets and provide insights into the origins of mammalian venom. Here we investigate the expression patterns of antimicrobial genes called defensins, and also the venom peptides called defensin-like peptides (OvDLPs). We show, in the first expression study on any platypus venom gene, that the OvDLPs are expressed in a greater range of tissues than would be expected for genes with specific venom function, and thus that they may have a wider role than previously suspected. (c) 2008 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
ORNITHORHYNCHUS-ANATINUS VENOM; AMINO-ACID-RESIDUE; BETA-DEFENSIN; PEPTIDE; EVOLUTION; BETA-DEFENSIN-1; CROTAMINE; ISOMERASE; CHICKEN; FAMILY
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-09-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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