Acquisition of invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein 1 in a transmigrant population requires multiple infections
- Author(s)
- Murhandarwati, EEH; Black, CG; Wang, L; Weisman, S; de Koning-Ward, TF; Baird, JK; Tjitra, E; Richie, TL; Crabb, BS; Coppel, RL;
- Details
- Publication Year 2008-10-15,Volume 198,Issue #8,Page 1212-1218
- Journal Title
- JOURNAL OF INFECTIOUS DISEASES
- Publication Type
- Journal Article
- Abstract
- Antibodies against the 19 kDa C-terminal fragment of merozoite surface protein 1 (MSP1(19)) are a major component of the invasion-inhibitory response in individuals immune to malaria. We report here the acquisition of MSP119-specific invasion-inhibitory antibodies in a group of transmigrants who experienced their sequential malaria infections during settlement in an area of Indonesia where malaria is highly endemic. We used 2 transgenic Plasmodium falciparum parasite lines that expressed either endogenous MSP119 or the homologous region from P. chabaudi to measure the MSP119-specific invasion-inhibitory antibodies. The results revealed that the acquisition of MSP119-specific invasion-inhibitory antibodies required 2 or more P. falciparum infections. In contrast, enzyme-linked immunosorbent assays on the same serum samples showed that MSP1(19)-specific antibodies are present after the first malaria infection. This delay in the acquisition of functional antibodies by residents of areas where malaria is endemic is consistent with the observation that multiple malaria infections are required before clinical immunity is acquired.
- Publisher
- UNIV CHICAGO PRESS
- Keywords
- PLASMODIUM-FALCIPARUM MALARIA; C-TERMINAL FRAGMENT; CLINICAL IMMUNITY; 19-KILODALTON DOMAIN; GHANAIAN CHILDREN; SERUM ANTIBODIES; ENDEMIC AREA; IN-VITRO; RESPONSES; PROTECTION
- Publisher's Version
- https://doi.org/10.1086/591943
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-10-15 12:00:00