Antigen-presentation properties of plasmacytoid dendritic cells
- Author(s)
- Villadangos, JA; Young, L;
- Details
- Publication Year 2008-09-19,Volume 29,Issue #3,Page 352-361
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation function. Instead, pDCs are regarded as immunomodulating cells, capable of directing the immune response through their secretion of large amounts of type I interferons. In this review, we examine the evidence for a potential role of pDC in antigen capture, processing, and presentation to T cells at sites of infection and in the lymph nodes.
- Publisher
- CELL PRESS
- Keywords
- MHC CLASS-II; INTERFERON-PRODUCING CELLS; RESPIRATORY SYNCYTIAL VIRUS; DRAINING LYMPH-NODES; SUBSETS IN-VIVO; T-CELLS; CROSS-PRESENTATION; CUTTING EDGE; ALPHA PRODUCTION; INFLUENZA-VIRUS
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2008.09.002
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-09-19 12:00:00