The B-cell response to protein antigens in immunity and transplantation
- Author(s)
- Tarlinton, DM; Batista, F; Smith, KGC;
- Details
- Publication Year 2008-06-27,Volume 85,Issue #12,Page 1698-1704
- Journal Title
- TRANSPLANTATION
- Publication Type
- Journal Article
- Abstract
- The potential for B cells to play a role in transplantation has been recently increasingly recognized. Given that the field has focused almost exclusively on the T cell, here we review B-cell biology. We first describe the B-cell response to protein antigen, and then examine the antibody-independent effector functions of B cells, in particular antigen presentation to T cells. Finally we use autoimmunity as an analogy to focus on the potential role for B cells in transplantation. The direct evidence for this is then marshalled in the accompanying article by Zarkhin and Sarwal.
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- ANTIBODY-FORMING-CELLS; FOLLICULAR DENDRITIC CELLS; DIFFERENTIATION IN-VIVO; GERMINAL-CENTER; PLASMA-CELL; LYMPH-NODE; IMMUNOLOGICAL-SYNAPSE; T-CELLS; RECEPTOR MICROCLUSTERS; AFFINITY MATURATION
- Publisher's Version
- https://doi.org/10.1097/TP.0b013e3181777a39
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-06-27 12:00:00