Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

Author(s): Cianci, J; Baell, JB; Flynn, BL; Gable, RW; Mould, JA; Paul, D; Harvey, AJ;
Details: Publication Year 2008-03-15,Volume 18,Issue #6,Page 2055-2061
Journal Title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Publication Type: Journal Article
Abstract: Chalcone derivatives of the natural product khellinone were synthesised and screened for bioactivity against the voltage-gated potassium channel Kv1.3. X-ray crystallography was employed to investigate relationships between the structure and function of a selection of the reported chalcones. (c) 2008 Elsevier Ltd. All rights reserved.
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Keywords: MEMORY T-CELLS; DERIVATIVES; AGENTS; FLAVONOIDS; ANALOGS; BLOCKER; DESIGN; POTENT; PAP-1
Publisher's Version: https://doi.org/10.1016/j.bmcl.2008.01.099
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2008-03-15 12:00:00