CD8(+) T cells are associated with severe gastritis in Helicobacter pylori-infected mice in the absence of CD4(+) T cells
- Author(s)
- Tan, MP; Pedersen, J; Zhan, YF; Lew, AM; Pearse, MJ; Wijburg, OLC; Strugnell, RA;
- Details
- Publication Year 2008-03,Volume 76,Issue #3,Page 1289-1297
- Journal Title
- INFECTION AND IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Helicobacter pylori infection results in the development of chronic gastritis, and CD4(+) T cells are a major component of the gastric cellular infiltrate. To examine whether CD4(+) T cells are important in initiating and maintaining H. pylori-induced gastritis, mice deficient in CD4(+) T cells (B6.BM1.GK 1.5 mice [GK 1.5 mice]) were infected with H. pylori. We found that as in normal mice, H. pylori-specific antibodies, mostly of the immunoglobulin M isotype, developed in GK 1.5 mice but were unable to cure H. pylori infection. Further, while the stomachs of H.pylori-infected GK 1.5 mice were more heavily infiltrated with CD8(+) T cells and B cells, mice deficient in both CD4(+) and CD8(+) T cells developed mild inflammation comparable to the level observed for C57BL/6 mice. These observations suggest that CD4(+) T cells may play an important role in regulating or suppressing gastric CD8(+) T cells which, in the absence of CD4(+) T cells, may mediate more-severe disease. These studies have revealed a potentially important role for CD8(+) T cells in the gastric disease resulting from H. pylori infection.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- PEPTIC-ULCER DISEASE; RESPONSES; MOUSE; MUCOSA; IMMUNIZATION; INDIVIDUALS; LYMPHOCYTES; PHENOTYPE; PATHOLOGY; SUBSETS
- Publisher's Version
- https://doi.org/10.1128/IAI.00779-07
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-03-01 12:00:00