The Ets transcription factor Elf5 specifies mammary alveolar cell fate
- Author(s)
- Oakes, SR; Naylor, MJ; Asselin-Labat, ML; Blazek, KD; Gardiner-Garden, M; Hilton, HN; Kazlauskas, M; Pritchard, MA; Chodosh, LA; Pfeffer, PL; Lindeman, GJ; Visvader, JE; Ormandy, CJ;
- Details
- Publication Year 2008-03-01,Volume 22,Issue #5,Page 581-586
- Journal Title
- GENES & DEVELOPMENT
- Publication Type
- Journal Article
- Abstract
- Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. Conversely, overexpression of Elf5 in an inducible transgenic model caused alveolar differentiation and milk secretion in virgin mice, disrupting ductal morphogenesis. CD61(+) luminal progenitor cells accumulated in Elf5-deficient mammary glands and were diminished in glands with Elf5 overexpression. Thus Elf5 specifies the differentiation of CD61(+) progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- GLAND DEVELOPMENT; BREAST-CANCER; STEM-CELLS; MICE; DIFFERENTIATION; PROLACTIN; PREGNANCY; DEFECTS; GATA-3
- Publisher's Version
- https://doi.org/10.1101/gad.1614608
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-03-01 12:00:00